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Description

This leads to endothelial dysfunction from augmented ROS production, inflammation, and eNOS deletion (88)

Correlation of adipokines and markers of oxidative stress in women with gestational diabetes mellitus and their newborns

It was originally developed as a potential anti-obesity drug due to its ability to influence fat metabolism without causing the same growth-promoting effects associated with full HGH therapy (review)

Consistent with this early developmental stage, published clinical data - including a first-in-human phase I trial of INCB001158 alone or combined with pembrolizumab (NCT02903914) and a phase Ib study assessing INCB001158 with or without retifanlimab in Japanese patients (NCT03361228) - primarily report safety, pharmacokinetics/pharmacodynamics, and only limited antitumor activity in small cohorts [171]