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For example, type 1 angiotensin-II receptor antagonist telmisartan used as an antihypertensive drug and H1 receptor antagonists, terfenadine used as antiallergic agent for many years, have been identified as potent CYP2J2 inhibitor at concentrations that are reached during clinical use and are well tolerated by patients, 510,511 because terfenadone strongly inhibited CYP2J2-mediated metabolism process

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doi: 10.7717/peerj.6368 270 AokiMUrakamiTNaganoNAokiRMoriokaI

Purified CFE systems, on the other hand, are well-defined but still involve many different components forming a complex biological reaction network

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