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observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )

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8 weeks: ~3 vials 12 weeks: ~6 vials 16 weeks: ~8 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 8 weeks: ~56 syringes 12 weeks: ~84 syringes 16 weeks: ~112 syringes Bacteriostatic Water (30 mL bottle) Use 3.0 mL per 12 mg vial for reconstitution

AOD-9604 does not affect IGF-1 because it lacks the receptor-binding domains necessary to activate growth hormone receptors

In rodent models, blocking NNMT with 5-Amino-1MQ led to lower fat mass, more energy burn, and better insulin response all without cutting calories