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ROS-induced damage to DNA, proteins, and lipids can directly lead to cell death, but it also promotes microglial activation and the release of pro-inflammatory cytokines, further exacerbating neurodegeneration (Tfilin et al., 2023)

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Nicotinamide deoxyriboside derivatives, such as nicotinamide 2-deoxyriboside and 5-methylnicotinamide 2-deoxyriboside, act as mechanism-based small molecule inhibitors of CD38 by forming stable covalent intermediates 132

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There are a number of limitations to the above approaches when quantifying reactive sulfur in biological systems: they only partially distinguish between H 2 S, RSS and RS(S) n S