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In fact, their unregulated sale and uncertain dosing pose unique dangers that may exceed those of controlled anabolic agents (Parssinen et al., Frontiers in Endocrinology )
The source of ROS in the insulin secreting pancreatic -cells and in the cells which are targets for insulin action has been considered to be the mitochondrial electron transport chain
Meanwhile, the NAD+/SIRT1 pathway maintains mitochondrial dynamic balance by regulating mitochondrial fusion and fission
Furthermore, a study by Zou et al
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