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Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

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Recently, membrane-bound O-acyltransferase 2 (MBOAT2), also known as LPCAT4, was identified as a GPX4/FSP1-independent ferroptosis suppressor via two-independent clustered regularly interspaced short palindromic repeats (CRISPR) screening assays 97,98

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In the fetus, fuel sources in the heart muscle are glucose and lactate, but in the neonatal heart, fatty acids are the main fuel that require the PPAR to be activated so it is able in turn to activate the genes essential for fatty acid metabolism in this stage