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All procedures were performed under the approval of the University Hospital Hamburg and the Hamburg State Department for Animal Welfare (N001/2020)

In addition, multiple-alignment analyses demonstrated the presence of a considerable degree of conserved residues in main sites of both enzymes

CPZ intoxication mimics several degenerative events in the brain, inducing demyelination, loss of OLs, axonal and synaptic dysfunction, glial cell activation, and oxidative stress, recapitulating cellular and molecular degenerative features of demyelinating diseases 31,32,33,34

doi: 10.1128/aem.54.2.600-603.1988