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doi: 10.1152/physrev.00010.2008 74 LiT.ChenY.GuaC.LiX

More specifically, IGF-1 LR3 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, and a 13 amino acid extension peptide at the N terminus from methionyl porcine Growth Hormone [1]

Induction of tumor cell apoptosis is related to the activation of pro-apoptotic proteins Bax, Cytc, caspases-3, 9 and the inhibition of Bcl-2 and Mcl-1 (169)

While GSH is essential for normal redox homeostasis, its upregulation in tumor cells contributes to chemoresistance and poses a challenge to effective cancer treatment

By integrating these insights, this review provides an interdisciplinary perspective to guide the development of next-generation botanical drugs for PD