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Essentially, the gap detection test is a variant of the PPI test, with the main distinction being that PPI occurs in a quiet environment 100 ms before a burst of white noise (50 ms at 110 dB SPL), preceded by a 50 ms pure tone (16 kHz, 70 dB SPL)

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Another meta-analysis also showed that prolonged treatment with higher doses of NAC (1200 mg/day) prevents exacerbations of COPD, while lower doses (600 mg/day) may be effective only for patients with chronic bronchitis, without COPD and without airway obstruction [57]

Tovar, S