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10.1016/j.cis.2021.102437 207 SanchezN

This constellation of findings indicates that GSH supplementation may be a viable treatment option for patients with IRIS or as a prophylactic agent in patients starting HAART

Theres some evidence linking decreased levels of SAMe in the body with the development of liver diseases, and animal studies have suggested that SAMe may be of value for liver problems
This increases the likelihood of the addiction aspect

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