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Although the addition of CMCs lowered the release rate of CM due to an increase of viscosity of the system, the accumulative release percentage still reached close to 90% (89% for PC202 and 81% for PC204) after 48 h
The American and Canadian Colleges of Obstetrics and Gynecology recommend the use of a delayed-release formulation of pyridoxine hydrochloride (vitamin B 6 ) plus doxylamine succinate (an antihistamine) as first-line therapy for nausea and vomiting during pregnancy
References 1.Reeves E.P., Messina C., Doyle S., Kavanagh K

61st Annual Meeting Southern Thoracic Surgical Association:92, 2014

However, more severe side effects can occur, such as difficulty swallowing, breathing issues, or blurred vision, although these are rare
