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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

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Its a very limited study and I dont know how accurate it was, I assume that the b12 wasnt the little vials that we use today hence the smaller amounts injected in the study

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The vitamin B12/IF complex enters the mucosal cells in the distal ileum by receptor-dependent endocytosis