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Macrophage migration inhibitory factor inhibits the antiinflammatory effects of glucocorticoids via glucocorticoid-induced leucine zipper

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The combination of different release patterns and mechanisms often produces superior results compared to single compounds

Copper coordination may be affected by pH, ionic strength, and chelating agents

Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results