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Both are generally considered safe for long-term use at standard supplementation levels

5 Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA regulation, are heritable changes in gene expression that do not involve alterations to the underlying DNA sequence

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Donorrecipient mismatch in FMT and poor colonization of many probiotic strains limit durable effect [274, 275, 321]

10.1053/beha.1999.0055 Baillieres Best Pract Res Clin Haematol
