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Furthermore, the coexpression of MC3R and GHSR1a in the hypothalamic arcuate nucleus suggests that this dimer may play a role in arcuate-mediated feeding behavior (Roselli-Rehfuss et al., 1993

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It plays a crucial role in protecting cells from oxidative stress and damage caused by free radicals

It represents a promising first-line treatment for DPN, preventing early development and progression through both direct and indirect antioxidant effects [8,23,71,87,110] (Figure 3)

For GSTM1 knockdown, HeLa cells were transfected with scrambled or GSTM1 siRNA (Dharmacon Inc., USA) using the Dharmafect-1 transfection reagent according to manufacturer's instructions