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doi: 10.1002/mds.27328 156 SpencerB.MichaelS.ShenJ.KosbergK.RockensteinE.PatrickC.et al

catalase, which breaks down hydrogen peroxide into water, oxygen, and glutathione peroxidase (GPx), which neutralizes hydrogen peroxide and lipid peroxides, preventing oxidative damage to cellular components such as lipids, proteins, and DNA [54,55]

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These results collectively indicate that Sirt1 is indispensable for NNMT-mediated regulation of glucose metabolism, and both NNMT and MNAM have the ability to upregulate Sirt1 expression
