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The NFB pathway is initiated by the degradation of IB, enabling NF-B to translocate to the nucleus and promote the transcription of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further damage endothelial cells and disrupt tight junction proteins (Figure 3) [188,189,190]

Metabolomics analysis based on UPLC-MS/MS showed that the MDR phenomenon in SW620/Ad300 cells was closely correlated with the upregulation of spermine and spermidine synthesis and D-glutamine metabolism

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Advise patients to discontinue use of the product if these symptoms occur and seek immediate emergency treatment