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Figure 1 Patients with GSSD, which is classified as mild, moderate, or severe based on clinical symptoms, usually show disease onset symptoms during the neonatal period ( 2
After treatment, patients may experience a sensation of warmth and tingling in the treated area, but this sensation typically fades quickly

Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]
