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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein: protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)

10.1161/CIRCULATIONAHA.106.179918

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Patients with poorly controlled T1DM exhibit a 23-fold increase in GH levels that result in significant metabolic abnormalities