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The gene encoding the APF peptide was found to be consistently overexpressed in IC/BPS patient bladder epithelial cells samples relative to controls as determined by Northern blot 27

[PMC free article: PMC209498] [PubMed: 11602619] 33

In 2017, scientists reversed-engineered that interfering with the FOX04-p53 interaction was critical to inhibiting senescence: The specificity of this peptide arises from its design that is based on previously published data on the FOXO3/p53 interaction

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This represents an indirect mechanism that could enhance the bodys natural repair processes rather than replacing them with an external signal