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10.1016/j.bioactmat.2023.09.020 120 ZengL.LiuY.WangQ.WanH.MengX.TuP.et al (2024)

TB-500 accelerates resolution of joint capsule inflammation

CCL2 , IL10 , IL1RA , and IL6 were not differentially expressed when impaired and non-impaired individuals were compared, and these genes did not respond to incubation with B12 (Additional file 4)

Additional contributing factors include increased expression of insulin-like growth factor 1 (IGF1) receptors, IGF1-binding protein (which protects IGF1 from proteolysis) in Purkinje cells [8], as well as upregulated mRNA expression of GLUT1 and GLUT3 [80]

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