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The penetration of NAC was investigated through pig skin using Franz diffusion cells, preparing four different solutions within N-acetyl-L-cysteine, with increases in the extent of NAC penetration shown in the following order: propylene glycol, water, ethanol, and propylene glycol containing 5% of azone

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Keywords: Coumarin, Anti-inflammatory, Herbal medicine, Bioactive compound, Cytokine Graphical abstract Highlights Coumarins show strong anti-inflammatory effects by modulating signaling pathways and inhibiting pro-inflammatory mediators