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As clinical signs of cobalamin deficiency include chronic wasting or failure to thrive, malaise, and gastrointestinal signs such as diarrhea, serum cobalamin concentration should be measured in any dog with poor response to enzyme replacement therapy for EPI

This article examines the historical evolution of medication-assisted treatment (MAT), explores current options, breaks down barriers to access and compliance, and previews promising new pharmacotherapies that could redefine addiction treatment in the years ahead