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In conclusion, these studies showed an effect of APOE on L-carnitine, its metabolites and acylcarnitines with age in the brain parenchyma and in the cerebrovasculature up to mid-life, which suggest differences in age-related bioenergetic shift between alleles

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Carnitine palmitoyltransferase 2 deficiency: the time- course of blood and urinary acylcarnitine levels during initial L-carnitine supplementation

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