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Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies

Micelles containing DSPE-PEG-GSH (between 0.2 and 10 mol %), which is synthesized before preparation of the liposomes using DSPE-PEG-MAL and fresh solutions of reduced glutathione (rendering a MAL-reactive thiol group in the cysteine moiety of the tri-peptide) and DSPE-mPEG (Mw 2000) is added to the solution at different mol-percentages (up to 5-10 mol % in total)

The same phenomenon has been observed in ARF19 and ELF3 condensates, both of which sequester TFs from accessing transcriptional targets 24,99