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In conclusion, these studies showed an effect of APOE on L-carnitine, its metabolites and acylcarnitines with age in the brain parenchyma and in the cerebrovasculature up to mid-life, which suggest differences in age-related bioenergetic shift between alleles

A very similar network of hydrogen bonds was also observed in the complex structure of the human succinic semialdehyde dehydrogenase (residues Arg 213 , Arg 334 and Ser 498 , compare Supplementary Figure S1) (Kim et al., 2009)

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This process is key to energy metabolism and is often mentioned in contexts of physical activity, especially when energy demand increases

In the l-carnitine group, 74.2% (23/31) of patients with impaired brain function and with normal ammonia levels had improved NIRS data at 8 weeks of treatment (Fig