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(5) Cognitive and vision health Low levels of ergothioneine in older adults have been linked with cognitive decline

With its dual localizations in the apical (the renal proximal tubule cells and the luminal side of brain capillary endothelium) and basolateral membranes (the prostate tubuloacinar cells, hepatocytes, and choroid plexus epithelium), MRP4 differs from other MRPs that are either located apically or basolaterally[95]

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Importantly, basal HO-1 expression levels, rather than HO-1 levels after oxPAPC treatment, strongly correlated negatively with the expression of proinflammatory cytokines such as IL-6 ( r = 0.36, p = 1.37 e 06), IL-8 ( r = 0.28, p = 2.41 e 04), CAMs such as VCAM1 ( r = 0.22, p = 3.31 e 03), UPR such as Activating factor (ATF)3 ( r = 0.40, p = 5.01 e 08)

doi: 10.1016/j.freeradbiomed.2020.02.027 68 WangX.LiS.YuJ.WangW.duZ.GaoS.et al