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These models ensure therapeutic agents are delivered at optimal times and doses, maximizing efficacy while minimizing systemic toxicity

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For instance, in a murine model, Hofmann et al

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129 For example, nanomaterials such as polydopamine, melanin-like particles, and CeO 2 are rich in phenolic hydroxyl groups or oxygen vacancies, which can effectively scavenge excessive ROS, block the NF-B/NLRP3 inflammasome signaling pathway, and promote the polarization of macrophages from the proinflammatory M1 phenotype to the reparative M2 phenotype

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