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According to a prior study, PD patients were observed with much greater levels of 8-OHdG in peripheral blood leukocytes than those of the healthy controls, and this difference was connected with the severity of PD (Stoessel et al., 2018)

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Importantly, NNMTi is highly selective and has no inhibitory effect on other SAM-dependent methyltransferases or NAD + salvage pathway enzymes