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Mice null for ALDH1A1 and ALDH2 exhibit Parkinson's disease-like age-dependent deficits in motor performance and significant increase in biogenic aldehydes

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents

Table 1 indicates the combination of quercetin with current antidiabetic drugs acting by different mechanisms and streptazotocin-induced animal studies further show their efficacy in reducing blood glucose levels in type 2 diabetic rats/mice

doi: 10.1016/0024-3205(84)90359-x

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