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Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use

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Antipsychotic-drug-induced striatal DA D2 receptor blockade produces initial disinhibition of gamma amino butyric acid (GABA)- and encephalin-containing striatal neurons after the disinhibition of the subthalamic nucleus

BMJ Open 8 , e021401