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[161] Behavioral treatments A 2018 systematic review and network meta-analysis of 50 trials involving 12 different psychosocial interventions for amphetamine, methamphetamine, or cocaine addiction found that combination therapy with both contingency management and community reinforcement approach had the highest efficacy (i.e., abstinence rate) and acceptability (i.e., lowest dropout rate)

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Depressive outcomes were evaluated using various assessment tools, among which HDRS, BDI, and MADRS were most frequently used

Conversely, there was a negative correlation between disease severity and the expression of CTLA-4, CD28, and CD40L (58)

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