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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

[23] Other symptoms of Vitamin B12 deficiency: As mentioned earlier, vitamin B12 deficiency can cause a wide range of symptoms, including but not limited to: a sore/red tongue [25] blurry vision loss of memory depression folate deficiency, which is often related to vitamin B12 deficiency

None will shift from NICE guidelines

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Vitamin B12 is crucial for normal cell division and differentiation, as well as the development and myelination of the central nervous system