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In the human AD brain GPX4 is downregulated at an early stage of the pathology, while upregulated at a later stage of the pathology [17]

This is due in part, to the fact that clinical trials usually engage adults 18-65 years old (152) and thus, the results drown from these studies often do not reflect the potential activity and side effects of a drug in children and elderly patients

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Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice