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For example, senescent astrocytes show upregulated expression of IL-6, IL-8, IL-1, MMP3, MMP10, and TIMP2, while neuroprotective factors such as IL-10, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) are downregulated (Lye et al., 2019)

Animal studies, predominantly from a single research group in Croatia, show accelerated recovery across muscle, tendon, bone, gut lining, nerve, and vascular tissue (Chang et al., 2011)

Metformin may result in suboptimal oral vitamin B12 absorption by competitively blocking the calcium-dependent binding of the intrinsic factor-vitamin B12 complex to its receptor

Several other groups showed that PGRMC1 enhanced chemoresistance in several cancer cells such as uterine sarcoma 43 , breast cancer 17 , endometrial tumour 13 and ovarian cancer 44,45