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The rats were orally treated with water (control), captopril (positive control, 200 mg/kg), and ECE (300 and 500 mg/kg) for 14 days

One strand of this duplex is incorporated into the RNA-induced silencing complex (RISC), which modulates gene expression predominantly by promoting mRNA degradation or inhibiting translation

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Here is the honest framing: the evidence on UMFA harm is not definitive
