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For many years, the medical treatment of RA has been basically based on the use of corticosteroids and traditional antirheumatic drugs (DMARDs), such as methotrexate (MTX) (Kerschbaumer et al., 2020)

This is typically administered via oral gavage or subcutaneous injection
Among drugs that have been approved in recent years, the average share of females in the trial population has been consistently reported since 2014 by the FDA, with the average share of 51 percent between 2014 and 2021, ranging from 37 percent in 2014 (six trials) to 57.1 percent in 2019

Allegaert K, de Hoon J, Verbesselt R et al , Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates
