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A meta-analysis of global birth prevalence of spina bifida showed that when mandatory fortification was compared to countries with voluntary fortification or no fortification program, there was a 30% reduction in live births with spina bifida, [36] with some countries reporting a greater than 50% reduction

20 studies were included

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It is widely believed that activation of the TH17 pathway by IL-23 is the predominant mechanism involved in the pathogenesis of psoriasis

This could possibly be carried out given its special interaction and modulatory effects with the nitric oxide (NO) system [43,44,45,77,78,79,80,81], thrombocytes [81,82,83], and many molecular pathways [36,37,43,44,45,46,47,48,49,50,51], particularly NO molecular pathways [43,44,45], which is a point also noticed in myotendinous junction recovery [13]