glutathione disulfide reductase activity Glutathione-Related Enzymes and Proteins: A Review 7: Enzymatic recycling of glutathione

Ilbert M, Horst J, Ahrens S, Winter J, Graf PCF, Lilie H, Jakob U (2007) The redox-switch domain of Hsp33 functions as dual stress sensor

(Increased PTH levels are associated with decreased bone mineral density)

[DOI] [PubMed] [Google Scholar] Poot M, Teubert H, Rabinovitch PS, Kavanagh TJ

A more recent population-based longitudinal cohort study that assessed GGT variability (a calculated index assessing the coefficient of variation, standard deviation, and variability independent of the mean) in 119,201 individuals found that higher GGT variability was strongly associated with a significant increase in the incidence of hospitalized heart failure, particularly among dyslipidemic subjects [65]

As presented above, the main molecular target for the peptide is NO, particularly eNOS-derived NO, which can act on a number of target enzymes and proteins