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These effects were absent in GPR109A knockout mice, indicating that podocyte protection is mediated by GPR109A activation (68)

This feature is attributed to its distinct amino acid composition and spatial arrangement

Dobric et al., 2007

Reported benefits (per available research): Studied for its ability to raise GH and IGF-1 toward youthful levels and blunt age-related loss of fat-free mass, based on a 2-year randomized, placebo-controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine, PMID 18981485)

The absence of safety data in these populations should inform clinical decision-making and prescribing practices