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The HGF/c-Met axis is involved in cell proliferation, movement, differentiation, invasion, angiogenesis, and apoptosis by activating multiple downstream signaling pathways

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[Crossref] [PubMed] Zhou B, Gitschier J

This finding is consistent with other reports that these genes expression typically peaks during early progenitor stage and decreases towards the final hepatocyte-like cells stage 24,25,26

Thus, even at this early stage in the process, GPCR-initiated signaling has the capacity for self-termination
