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These LDSFs primarily act on VECs, VSMCs, cardiomyocytes, fibroblasts, macrophages and platelets, and the predominant underlying mechanisms involve the regulation of eNOS/NO, endothelial function, energy metabolism, inflammation, oxidative stress, and dystrophic calcification (Fig

High doses too frequently may lead to rare side effects like low potassium or vascular stress

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IGF-1 acts mostly as an endocrine hormone secreted primarily by the liver [2,3] and transported to the target tissues

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