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We have recently demonstrated that a high dietary fat intake increased prostate 5 -reductase-2 gene expression and circulating DHT levels in the rat without significant alteration in prostate and hepatic 5 -reductase-1 gene expression and plasma testosterone concentration 94 , suggesting that alteration in prostate 5 -reductase activity after a high-fat diet may be a potential mechanism for dietary fat stimulation of prostate growth and pathogenesis (Fig