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Furthermore, the study results demonstrate that GSH treatments significantly reduce ROS accumulation in ethanol-treated HepG2 cells and in vivo models, highlighting their potential in mitigating alcohol-induced oxidative stress

Removal of the first three amino acids from the native IGF-1 N-terminus yields a truncated 67-amino acid analogue with markedly altered binding protein interactions

At present, it is widely accepted that GSH acts not only as a reducing agent and a major antioxidant within the cells, but also as a mediator of many other physiologic reactions including metabolism of xenobiotics, thiol disulfide exchange reactions, and cellular signaling (cell-cycle regulation, proliferation, and apoptosis)

doi: 10.1126/science.1166304

Future research should prioritize addressing these issues to further elucidate the role of ferroptosis in depression and provide targets for the development of new antidepressant medications