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3 In normoxia, HIF1A protein is targeted for degradation by cytosolic prolyl hydroxylases, while in hypoxia, these prolyl hydroxylases are inhibited, allowing HIF1A to translocate to the nucleus, dimerize with HIF1 protein, and the dimer then binds to hypoxia response elements to modulate transcription of target genes, prompting changes in metabolism and angiogenesis to promote survival

doi: 10.1021/cn5001759

Protects neurons by improving mitochondrial function

SLU-PP-332 is frequently discussed as a potent but non-selective ERR agonist with strongest activity reported at ERR in vitro, making it a useful tool for comparative receptor studies and pathway mapping

Taylor-Cousar JL, Munck A, McKone EF, et al