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Nat Rev Rheumatol, 2011

Not recommended for pregnant or breastfeeding women

An RNA-binding protein, RBMS1, interacts with eIF3d to bridge the 3- and 5-UTR of SLC7A11, facilitating its translation

In the altered scenario of cholestasis, the retention of more hydrophobic bile salts, such as the glyco- and tauro-conjugates of deoxycholate, plays a major part in the onset of liver injury, causing hepatotoxicity due to mitochondrial dysfunction and production of ROS, with consequent oxidative damage [181,182]
