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Mitochondrial dysfunction has been implicated in several neurodegenerative diseases, including Alzheimers disease, Parkinsons disease, and Huntingtons disease [49]
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Glutathione reductase: regulation and role in oxidative stress, in Oxidative Stress and the Molecular Biology of Antioxidant Defenses ed J

However, future studies are needed to delineate the presence of p-tau epitopes that are emerging as fluid-based biomarkers in AD, e.g., Thr181 and Thr217, early, soluble p-tau sites that cause detachment of tau from microtubules, e.g., Ser214, and other p-tau sites that enhance tau seeding capacity, e.g., Ser262

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