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, Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and 5, but not IGF-II or IGFBP-4

This splice variant occurs via an alternative promoter and results in an open reading frame that is identical to the C-terminal half of the full ATP7B protein

Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C , Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, Lovejoy C, Leeds JM, Hruby DE, Jordan R

10.1016/j.csbj.2021.02.009 211

Thus, extracted natural-based peptide has been shown markedly retarded angiogenesis