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Indeed, an intact VN appears necessary for certain antisteatotic reflexes: leptin's ability to reduce liver fat depends on vagal signaling to stimulate triglyceride export from the liver, further highlighting the vagal role in lipid metabolism (Metz et al

Increased pro-oxidant or decreased antioxidant defense is considered a promising therapeutic option as excessive ROS production beyond a threshold value leads to cancer cell death

The presence of perilipins A and B coating the lipid droplet is believed to function as a protective barrier that restricts access of TAG lipases to neutral lipid substrates in order to prevent unrestrained basal lipolysis (15)