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Hepatic glutathione stores are prioritised over systemic circulation, meaning only 1015% of an oral dose reaches peripheral tissues where oxidative stress from lipolysis is highest

Meanwhile, the multifaceted roles of nutraceuticals, including polyphenols, vitamins, and the Mediterranean diet, in modulating oxidative stress, neuroinflammation, and mitochondrial dysfunction have been extensively studied (Soni et al., 2024)

These include complement and cells bearing FcRs, which can directly mediate antibody effector activities or indirectly, via antigen presentation, enhance cellular immunity

Further research is essential to fully elucidate these pathways and their implications for therapeutic applications

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